Ana Ortega-Molina, from the Spanish National Cancer Research Center in Madrid, and colleague, have found that a gene, P10, is Linked to Longevity and Weight in Mice. The researchers found that mice with extra copies of the said gene are protected from cancer and hence live long; and also have increased energy expenditure, as a consequence have hyperactive brown fat, and thus stay less weighty.
The experimental study is published in the March 7 issue of Cell Metabolism.
The researchers had a previous understanding about one of the phosphatidylinositol 3-kinase type I (PI3K) pathways regulating aging in worms and flies; and P10 counteracting PI3K. This led the team investigate the role of P10 in mice carrying additional copies of the P10 gene.
The researchers found that the extra copies of P10 gene not only protected the mice from cancer and helped them live long; but also protected the mice from insulin resistance and diet-induced steatosis. As a consequence, the mice weighed less and had increased energy expenditure and protection from metabolic pathologies. That apart, the said mice were also found to have brown adipose tissue that was hyperactive.
The researchers note that, the extra copies of P10 induced the same results, which is also induced by a synthetic PI3K inhibitor, that is — Increase energy expenditure and hyperactivation of brown adipose tissue. A key to ensuring a weight normal.
The Researchers are enthusiastic about delving more into unraveling the role of Pten in promoting energy expenditure, thus decreasing nutrient storage and its associated damage, and helping ensure a normal body weight.
Hope, the next in line is linking the findings of the study to humans, a population most affected by over-weight and obesity.