Diabetes in Adult women and obesity after 60 years of age increases Breast Cancer Risk

According to a Swedish study, reported at the 2011 CTRC-AACR San Antonio Breast Cancer Symposium, held Dec. 6-10, 2011,

Having diabetes or being obese after age 60 significantly increases the risk for developing breast cancer. The study data also revealed that high blood lipids(Good fat) were less common in patients when diagnosed with breast cancer, while low blood lipids were associated with an increased risk.

The Researchers also looked at overall cancer incidence and discovered that use of one diabetes drug was associated with a lower rate of any cancer, while another was associated with an increased risk [Ask your doctor about the Safe drug].

How the Researchers conducted the study:

Researchers evaluated health care data from a region of 1.5 million people living in Southwestern Sweden to provide a comprehensive picture of cancer risk. The researchers examined the records of 2,724 patients up to 10 years before they developed cancer and 20,542 patients who never developed the disease.
Findings of the Study:

After studying both male and female participants, the researchers found that diabetes in adult women and obesity in women aged 60 and older significantly increased breast cancer risk, informed Håkan Olsson, M.D., professor in the departments of oncology and cancer epidemiology at Lund University.

The researchers found that obesity in women after age 60 increased risk for developing breast cancer by 55 percent. At the most, 15 out of 100 obese women would get breast cancer compared with slightly less than 10 out of 100 in the general population.

Women with diabetes had a 37 percent increased risk for developing breast cancer if their diabetes had been diagnosed up to four years before cancer was diagnosed.

Women with abnormally low levels of blood lipids (mostly cholesterol) had a 25 percent greater risk for developing breast cancer, while high levels of blood lipids appeared to be associated with a lower risk for breast cancer. The mechanisms behind these effects are unclear, and the finding needs to be replicated in a different population-based study.

The study underlined that the findings are useful information for women who want to know their risk and who can take steps to lower it.

Role of a particular drug in increasing the risk of breast cancer:

Researchers also looked at the national drug prescription registry to examine the link between risk for all cancers and use of two diabetes drugs, glargine and metformin. In this study, investigators found that glargine use, which had been associated with increased cancer development in previous European studies, almost doubled the risk for development of any cancer, while metformin was linked to an 8 percent lower risk for cancer in patients with diabetes.

The researchers are quick to underline more research is needed to clarify the specific cancers at increased risk. The number of patients in this study who developed breast cancer using these medications was too small to make any link to breast cancer risk, specifically.

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